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Minimal Cascade Model for a Mitotic Oscillator

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Albert Goldbeter modified a model with enzyme cascades [Goldbeter and Koshland 1981] to fit cell cycle data from studies with embryonic cells [Goldbeter 1991]. He used this model to demonstrate thresholds with enzyme cascades and periodic behavior caused by negative feedback.

There are two SimBiology model variations using Goldbeter's model. The first model uses the differential rate equations directly from Goldbeter's paper. The second model is built with reactions using Henri-Michaelis-Menten kinetics.

• Goldbeter Model

• SimBiology Model with Rate Rules

• SimBiology Model with Reactions

• References

Model Reference

Goldbeter Model



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